Diabetic Ketoacidosis (DKA) Explained Clearly – Diabetes Complications
Understand Diabetic Ketoacidosis (DKA) with this clear explanation from Dr. Seheult of .
This is video 1 of 2 on diabetic ketoacidosis (pathophysiology and signs of diabetic ketoacidosis / DKA):
0:08 DKA stats
0:47 DKA – cellular anatomy
1:00 mitochondria
1:48 beta-oxidation
2:30 insulin function
3:08 pyruvate
3:19 diabetes mellitus type 1
3:26 diabetes mellitus type 2
4:48 ketone bodies (acetone, acetoacetate, b-hydroxybutyrate)
6:09 carboxylic acid
6:23 conjugate base (anion gap acidosis)
7:38 beta-oxidation
8:17 DKA review
8:57 diabetic ketoacidosis – hyperkalemia
9:37 diabetic ketoacidosis – dehydration
9:50 osmotic diuresis
10:10 dehydration
10:27 diabetic ketoacidosis – potassium effects
11:04 diabetic ketoacidosis – Cr elevation / renal failure
11:30 anion gap metabolic acidosis
12:09 measuring ketone bodies (serum ketones, b-hydroxybutyrate)
Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram: Medical topics explained clearly including: Asthma, COPD, Acute Renal Failure, Mechanical Ventilation, Oxygen Hemoglobin Dissociation Curve, Hypertension, Shock, Diabetic Ketoacidosis (DKA), Medical Acid Base, VQ Mismatch, Hyponatremia, Liver Function Tests, Pulmonary Function Tests (PFTs), Adrenal Gland, Pneumonia Treatment, internal medicine, usmle prep, dka, and many others. New topics are often added weekly- please subscribe to help support MedCram and become notified when new videos have been uploaded.
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Recommended Audience: Health care professionals and medical students: including physicians, nurse practitioners, physician assistants, nurses, respiratory therapists, EMT and paramedics, and many others. Review for USMLE, MCAT, PANCE, NCLEX, NAPLEX, NDBE, RN, RT, MD, DO, PA, NP school and board examinations.
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Produced by Kyle Allred PA-C
Please note: MedCram medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your health care provider.
Great video!
I almost died from dka 18 years ago. I was a newly diagnosed type 1 and was still learning how to manage my diabetes. I went to work and forgot my insulin and tester, I figured I could get through the day without it. At the end of my shift I started to feel nauseated and like I was getting the flu. I had a 1.5 hour commute home and during that time I was pulling over to vomit all the way home and felt like death. I finally made it home and immediately crawled into bed because I felt so awful. I didn’t check sugars because I was so out of it. I passed out and went into a comatose state. Thank God my girlfriend came over a few hours later and found me. I don’t remember anything but she told me I was basically dead, barely breathing and ghostly white. Thanks to great doctors and nurses about one week later I was well enough to go home from the hospital, with no lasting damage.
Great lecture. In case anyone is curious, the reason why the Acetyl COA (ACA) made from B-oxidation doesn’t go through the Krebs cycle here is because in diabetes there is also a lack of Oxaloacetate (OAA). OAA gets depleted for gluconeogenesis to provide glucose for the brain. (In Krebs Cycle, the first step is combination of ACA and OAA to make citrate.)
I’m a 4th year med student studying for Step 2 CK and this helped a lot! I like the organic chem structures too….gave me tons of nostalgia!!
@Sim Simma Good to hear- thank you for the feedback
I wish you were my lecturer, I would ace all my exams, Thank you for this great video and all your other content!!!
@Andile Kheswa thank you for the feedback
Not even in medical school yet but I still enjoy all this stuff! Thanks for helping me satisfy my knowledge cravings!
Omg such a genius
Wilson Lei you’ll do well!
MEDCRAM, aka Dr. S, I have listened to almost all your lectures as I was preparing for my nclex-rn exam and I was able to understand the concepts so much better having listened to your explanations and then re-reading the books again. I only wish I had done this sooner so that I could’ve taken this exam a lot sooner instead of rescheduling it every time I had a panic attack. To whoever out there that is listening to Dr. S’s videos, if you are hoping to learn from him, then you are at the right place. Do your readings, then listen to him explain it, then go back and review your notes again and again. That’s what I did as I was studying. The biggest hurdle is to not panic when you’re studying, just keep studying and reviewing, and review these concepts over and over again if needed, and you’ll be prepared when the exam day comes around. Keep the faith. You’ll pass. I have just taken my nclex-rn and passed with 75 questions and Dr. S was a big part in helping me achieved this dream. Thank you for making these videos. They are a tremendous help!!
As an individual with type 1 Diabetes for 9 years. This has helped me see what DKA is more than any doctor I’ve had could explain. Thank you.
This helps a ton! Its been a while since I’ve had this in school. Thanks for the refresher!
Great to hear, thanks!
I love this videos. Should the phosphate level be high prior to giving insulin for a patient with DKA? Phosphate is needed for glycolysis and there’s a lack of insulin or inability of the cell to respond to insulin in DKA, therefore, phosphate can’t go in the cell to help metabolize the glucose.
I just found your channel, and I LOVE your videos. You are seriously helping so many people – for example I’m a home care nurse and the most I do is actually teaching to my patients, but I was never taught well in school and have to self study. So glad you have HF here!! it seems like everyone has HF and DM!
@hammypie Glad the videos have been helpful for your home care nursing work- thanks so much for the feedback
Mate, awesome vid, I like how intricately you explain DKA yet still make it relatively easy to comprehend, love it!
I really enjoy your lectures. I’ve never felt so aware. Thank you so much! I’m a paramedic intern btw.
Please do HHNK next! 🙂
not really relevant for a paramedic to understand this lvl of detail is it?
Great lecture 🙂 thanks a lot MED CRAM
Thank you, this answered so many of my questions! I have a fourteen year-old child who has had type 1 for nine years, and he had a DKA episode this year. His first, and hopefully last.
Another awesone lesson.thought u were going to leave me hanging on why K+ was High but low@same time but u ended w/ great explication. Thanks again.
This is so well done. I really really appreciate it, thank you.
Every time I ask “why” in my head, you answer lol I love it thanks ?
This is wonderful! Thanks for sharing this!! 🙂
@Sarah Lemire Thanks for your feedback- glad the video was helpful
Excellent video! I am an RN but I like to know the how and why of everything in life, sometimes it is just too much information but you have a way of sorting out the tangle and presenting it with the how and why, love that. Thank you!
Lisa Towe Likewise. I also like to know the “why” behind everything in life!